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Using insulin secretion as a read-out in primary human islets provides a platform to interrogate this question in a system that is intimately linked to the glycemic benefits of tirzepatide
Tirzepatide was used at 30 nM and the antagonists were used at 1M concentrations
Although GLP-1 receptor agonists do not completely eliminate dopamine function, these medications appeared to reduce substance-induced dopamine activity without consistently suppressing baseline dopamine signaling
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