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In the intervention group, the dose of luseogliflozin will be increased to 5 mg if the principal investigator or sub-investigator concludes that the 2.5-mg dose of luseogliflozin did not sufficiently improve the pathological condition by decreasing the levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyl transferase (GGT) to normal levels

For consistency, try to use the same general area for at least one full dose cycle (four weeks at the same dose) before switching sites