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The most common side effect is irritation at the site of injection which could last up to 5-10 minutes
Presented for research literature review only Agius C et al
Starting with 1 mg daily for the first week, then adjusting based on tolerance and initial response, provides a conservative approach
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Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output
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