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In the folate cycle, serine to glycine conversion produces 5,10-meTHF, which is oxidized to 10-formyl-tetrahydrofolate (formate/10-formyl THF) 6
One of those dual agonists, tirzepatide (Mounjaro/Zepbound, Eli Lilly), was associated with a mean 14.7% weight loss for adults with overweight or obesity and type 2 diabetes in the SURMOUNT-2 trial compared with a 3.2% weight loss with placebo
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