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10.3389/fendo.2022.931573 21 de Pablo-FernandezE.GoldacreR.PakpoorJ.NoyceA
The gut releases it in response to food intake
Once acid reflux stabilizestypically within 4-6 weeks of starting or after dose adjustmentsmost patients resume their therapy progression without further digestive complications
Furthermore, impaired cerebral metabolism appears to be an early-stage biomarker for ADRD, as several studies have shown reduced glucose metabolism in the hippocampus and posterior cingulate prior to observation of overt clinical symptoms (i.e., cognitive impairment) (Kumar et al., 2022
PMID: 40134805
Last, development of new anti-TNF- forms and sophisticated TNFR targeting might optimize drug bioavailability, enhance their local efficacy and minimize adverse effects, while combination with other agents might refine disease outcomes using lower drug doses
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