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Finally, transcriptomic profiling was performed in behavior-naive offspring to eliminate experience-dependent confounds, precluding direct molecularbehavioral correlations
Karademir, E
Beyond glucose control, semaglutide activates neural pathways that influence mood, motivation, and metabolic stress responses
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In a model of non-ischemic HF in dogs (tachycardiomyopathy induced by pacemakers), IV infusion of GLP-1 increases left ventricular (LV) contractility (LV dP/dt increased by 98%, stroke volume by 102%, and cardiac output by 57%) and decreases LV end-diastolic pressure, heart rate, and systemic vascular resistance
tirzepatide activates the GIP and GLP-1 incretin receptors and adds a glucose-dependent insulin-secretion effect that an amylin analog does not have
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