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(2020) specifically addressed NSAID-induced gut damage a clinically relevant injury model and documented that BPC-157 administration stabilized the claudin-4 and occludin tight junction proteins that are degraded by NSAID exposure, providing a mechanistic explanation for the peptides permeability-protective effects

doi:10.1016/j.ghir.2009.03.001 Ionescu M, Frohman LA