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Selenium cysteine (Sec) is the catalytic activity neutral of GPX, and its activity is closely related to the level of selenium content in the body

thaliana , demonstrating the importance of an antioxidant system in defense against the fungus, which is known to cause oxidative stress in infected host tissues (Mulema et al., 2011)

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Therefore, strategies designed to target glutamine metabolism should consider the combined blockade of these transporters

Treatment with the selective GLS1 inhibitor BPTES reduced glycolysis and ameliorated lupus-like disease and EAE in MRL/lpr mice ( + CD4 - CD8 - cells), the urinary albumin/creatinine ratio, glomerular nephropathy score, and T-cell infiltration with IL-17A in the kidneys, relieving the EAE disease activity ( + T cells by inhibiting GLS1, glycolysis, and CD4 + T-cell differentiation in vitro by reducing the level of HIF1 protein, a key metabolic sensor in Th17 cells ( Table 1 )

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, et al