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the daily dietary fibre intake in hominins (who mainly consumed grasses and sedges) is estimated to have been over 100 g, while the modern western diet often results in daily intake below 15 g

Making dietary adjustments, such as avoiding gas-inducing foods like beans or carbonated drinks, might help alleviate this discomfort

Further studies revealed that GLC increases melanin production in melanocytes by three pathways, 1) activating activator protein-1 (AP-1) and CRE promoter to activate p42/44 MAPK signaling, 2) activating cAMP signaling, and 3) decreasing GSK3 phosphorylation while inducing CREB phosphorylation (Lee et al., 2005)

Needless to say, there seems to be evidence of both an association of low B12 and early greying, and a reversal of early greying following B12 supplementation

Antioxidants (Basel) , 12(1), 137

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