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In 1987, GLP-1 (736) was recognized as a physiological incretin in the studies of Kreymann et al
Some studies suggest GLP-1 receptor agonists may improve menstrual regularity and natural pregnancy rates in women with PCOS, likely because of improvements in weight and insulin resistance
Wegovy is currently only approved for obesity, while Ozempic and Mounjaro are FDA-approved for type 2 diabetes treatment
This shows that initial weight loss isn't enough
Despite these findings, the direct impact of GLP-1R signaling on T cell biology remains to be fully elucidated
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