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Here we report the development of artificial Met-activating dimeric macrocycles
Molecular weight approximately 340 Da (peptide) + copper ion
KH815 has been shown to produce a more potent antitumor effect than single TOPI inhibitor-TROP2-targeting ADCs as well as the ability to overcome drug resistance in preclinical cancer models, and is currently being investigated in a phase I clinical trial in patients with advanced solid tumors (NCT06885645) 237
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