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Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake
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This likely reflects the balancing effects of GLP-1 and GIP receptor activation, including glucose-dependent insulin secretion and reduced energy intake
These may have more adverse side effects and additional risks
Exploring lifestyle changes first may also help before switching.
The pharmacological explanation is straightforward
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