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These elevations are consistent with their accumulation in fibrotic lungs and their potential involvement in mTORC1-driven fibroblast activation [133, 134]
In a chronic social defeat stress model in mice, 21 days of oral administration at 0.1 mg/kg corrected depressive-like behavior, restored motor activity with a therapeutic effect of 60 percent, completely recovered anhedonia, restored synaptophysin levels (74 percent therapeutic effect), and fully restored CREB levels in the hippocampus
J.PangM
Because it is supplied as a finished liquid rather than a lyophilized powder, this format also simplifies inventory management for labs running multiple concurrent studies, since there is no calculation step to convert milligrams into a working concentration before each session
For long-term storage of unused lyophilized powder, freeze per manufacturer instructions (often -20 C or -80 C)
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