In some cases, new moles or dark spots may develop as melanin levels increase
This depends on your desired final concentration
At the same time, these medications reduce the amount of glucagon, a hormone that signals the liver to release sugar, preventing excessive sugar production
In a subgroup analysis of 32,695 patients with preexisting DR, there was no association seen for GLP-1 RAs with proliferative DR or diabetic macular edema, but associations were seen with a lower occurrence of vitreous hemorrhages, neovascular glaucoma, or blindness (hazard ratios, 0.74, 0.78, and 0.77, respectively)."GLP-1 RAs may be a factor in reduced rate of vision loss leading to blindness, even among individuals with preexisting DR," the authors write
Efforts continue to refine receptor targeting
Many patients using tirzepatide also consider inositol supplementation for metabolic support, particularly those with insulin resistance or polycystic ovary syndrome (PCOS)