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Semaglutide and Risk of Adult-Onset Seizure: A Target Trial Emulation [PMID: 42308439] Laboratory literature summary: Semaglutide and Risk of Adult-Onset Seizure: A Target Trial Emulation
Mean baseline body weight was 99.8 kg and mean BMI was 35.7 kg/m 2
Vascular and antioxidant peptides (BPC-157, GHK-Cu) potentially most relevant for diabetic complications
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STEP-4 trial data demonstrated 14% body weight rebound following Wegovy discontinuation at 68 weeks , establishing clinical justification for long-term GLP-1 therapy that insurers and national health technology bodies are progressively incorporating into obesity management protocols
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