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Now, researchers have uncovered another possible benefit

Retrieved December 4, 2025, from Qi, Z., Guo, W., Zheng, S., Fu, C., Ma, Y., Pan, S., Liu, Q., & Yang, X

Based on the multidisciplinary expert consensus on managing GLP-1 GI side effects: While dehydration can affect anyone on GLP-1 medications, certain groups face higher risk: GI tolerability of semaglutide 2.4 mg (STEP 1-3 pooled analysis) 74% GI adverse events in semaglutide group vs 48% placebo

There have also been documented local skin reactions when using GLP-1 RAs, particularly with the long-acting formulations

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