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In contrast, high oral doses of free lipoic acid (50 mg) significantly, yet transiently, increase the concentration of free lipoic acid in plasma and cells

It is important to note that a recent study revealed the opposite result with high doses of atorvastatin (40 m) in human cardiomyocytes and murine skeletal muscle cells, which is consistent with the adverse muscle effects of atorvastatin [229]

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However, the increase of glutathione (GSH+GSSG and separate GSH and GSSG forms) during HR was more dynamic and stable