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Pharmaceutical inhibitors like finasteride block both types systemically, which explains their effectiveness but also their side effect profile

5564 years, OR 2.31, 95% CI = 1.51 to 3.55

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Together, these data indicate that while persister cells likely contribute to treatment failure in some settings, they are one of several interacting mechanisms, alongside matrix sequestration, efflux activity, and metabolic heterogeneity, that produce the high tolerance of Candida biofilms

Animal models also indicated selenium deficiency induced oxidative stress and inflammation lead to lung fibrosis 28

MOTS-c does not produce acute effects after a single injection