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Aim for seven to eight hours per night

Using jepi-info program for sample size calculation and reviewing results from previous study 8 , sample size of 30 patients were sufficient to explore and achieve the study objectives

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It appeared that the muscle loss was less than fat

Retatrutide binds three receptors: the GLP-1 receptor (regulates appetite, insulin secretion, and gastric emptying), the GIP receptor (influences insulin response and adipose handling), and the glucagon receptor (affects energy expenditure and hepatic lipid handling)

Oxidative stress Reactive oxygen species can impair enzymes, damage mitochondria, increase glutathione demand and intensify pathway inhibition