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In most cases, however, the modest heart rate increase associated with GLP-1 receptor agonists can be managed effectively in the primary care or endocrinology setting with appropriate monitoring and patient education

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For a brief description, GLP-1RAs attenuate and stabilize the development of atherosclerotic plaques through anti-inflammatory mechanisms and preventing vascular remodeling, and inhibit activation and recruitment of macrophages in atherosclerosis

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However, given the short half-lives of sitagliptin and exenatide, the impact of the lack of a washout period was likely not clinically relevant (55, 56)