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This serves two purposes

Most remain stable for 28-30 days when properly stored

The recommended approach is to try conservative management strategies first (cool compresses, antihistamines, clothing changes), then consider dose adjustment if symptoms persist beyond 4 weeks, and only discuss discontinuation if symptoms are severe and unresponsive to other interventions

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3 and 4 report results of the effects of each OMM on endpoint waist circumference and BMI (percent reduction from baseline)

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