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ROS play an important role in microbial decontamination either directly by inducing oxidative stress or indirectly by promoting pathogen clearance through a number of non-oxidative mechanisms, including autophagy, T-cell responses, and pattern recognition receptor signaling 44
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In contrast, GLP-1 receptor activation has consistently reduced MACE in randomized trials 26,27
4.3.1 Cardiovascular outcomes in GLP-1 RAs studies The ELIXA trial, which included 6068 patients, was the first to investigate the cardiovascular effects of GLP-1 RAs
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