They are not necessary, but they are useful if whole food protein is not achievable
Circulation (2004) 110(21):330612.10.1161/01.CIR.0000147829.78357.C5 204 KuhnM
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The margin of error is +/- 4.1 percentage points at the 95 percent confidence level, including the design effect
Schmidt, R
While extensive studies have focused on leptins actions in the hypothalamus in the regulation of feeding and energy metabolism [10, 11], LepRb is also highly expressed in extra-hypothalamic brain regions including the hippocampus, which is implicated in mood regulation [4, 12,13,14]