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US Pharmacopeia

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Outlook The GLP-1 agonists are an impressive new option for weight loss, especially in the setting of type 2 diabetes due to their glucose-lowering benefits

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Newer platforms, such as spatial transcriptomics and single-cell proteomics, may provide insight into the tissue localization of inflammatory and microbial signals in atherosclerotic plaques

Given the challenges obesity poses in this fieldincluding increased perioperative risk, altered musculoskeletal biomechanics, and poorer long-term outcomesGLP-1 agonists may play a valuable role in optimizing orthopedic surgical care