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Nrf2 induces Ucp1 expression in adipocytes in response to 3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice

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Exploring the Discrepancy Between Cell Culture and Animal Studies

In this context, several sensors and pathways regulating the transcription factors, such as activator protein 1 (AP-1), cAMP response element-binding protein (CREB), hypoxia inducible factor-1 (HIF-1), nuclear factor B (NF-B), activating transcription factor 4 (ATF-4), and nuclear factor-erythroid 2-related factor-2 (Nrf2), have been described (Marinho et al