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While there is limited evidence regarding tirzepatide use specifically in patients with significant thyroid disease (as these patients were typically excluded from pivotal trials), there is no established direct pharmacological interaction between tirzepatide and Graves disease pathophysiology
But last week, the 37-year-old posted a teary five-minute-long apology video sharing that after trying it all (keto, macros, workouts, lifestyle shifts), she decided to add a GLP-1 medication to her weight-loss regimen last year
This does not mean none exists, but no interaction has been documented yet
The cycle repeats because it feels productive in the moment
4.3 Nervous system disorder Recently, a protective effect of the GLP-1/GLP-1R axis on ischemic brain injury has been emphasized
The most frequently reported TEAEs with semaglutide were gastrointestinal disorders, which are considered a class effect of GLP-1RAs
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