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Zepbound is approved for those with a BMI of 30 or greater
In the United States alone, more than 6 million obese or overweight people have cardiovascular disease but not diabetes
All three sit in the same pharmacokinetic tier (5 to 7 days) and all three use once-weekly subcutaneous injection
If you take any of these alongside Ozempic, make sure your provider knows so they can assess the combined picture
GLP-1 RAs STEP 1 (2021) : Semaglutide 2.4 ./ 14.9% 68 2.4% (Wilding et al., 2021, NEJM) SURMOUNT-1 (2022) : Tirzepatide (GLP-1/GIP dual agonist) 15 ./ 20.9% (Jastreboff et al., 2022, NEJM) GLP-1 HbA1c () 2 (Hypoglycemia) Glucose-dependent LEADER (liraglutide) SUSTAIN-6 (semaglutide) 2024 FDA Semaglutide (Wegovy) FLOW (2024) semaglutide (MASLD/NAFLD) GLP-1 RAs GLP-1
Yamanaka A, Beuckmann CT, Willie JT, et al
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