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What we know today comes from two sources: controlled clinical trials (STEP, SELECT, SURMOUNT) and the collective experience of over 1.5 million Americans using these medications as of January 2026

doi: 10.1016/j.urology.2004.10.060

2 NO and vascular function NO is a vasodilator that activates soluble guanylate cyclase (sGC), lowers intracellular calcium, relaxes the vessel wall, and maintains antithrombotic endothelial function

Nitric oxide system modulation: The peptide interacts with the nitric oxide pathway, which regulates blood flow, inflammation, and cellular signaling

J Gastroenterol Hepatol 2012;27:16951704

All decisions regarding your pet's care should be made in consultation with your primary veterinarian