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Among these elements, ATF3 predominantly regulates the basal and stress-induced expression of ChaC1 through ATF/CRE, while ATF4 primarily regulates stress-induced ChaC1 expression through ATF/CRE and ACM (48)

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It has also been described that curcumin, as well as other bioactive phytochemical with similar structures at concentrations between 50 and 500 M, can specifically inhibit HDACs both at the level of activity and expression

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