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This system demonstrates significantly improved antitumor efficacy in both small cell and non-small cell lung cancer models (174)

Lipid metabolism undergoes broad enhancement throughout the different stages of BC, serving as both an energy source for tumor cells and a trigger for specific signaling pathways and aberrant cellular activity (Figure 2)

Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane

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The activity of several hepatic nuclear receptors is reduced in patients with Wilson disease and in Atp7b-/- animal models, though it remains unclear how this contributes to the diseases pathogenesis [130]