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It is more likely to occur in those patients receiving too much of the medicine but can occur with small doses as well

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A 12 months longitudinal study

Interestingly, whereas the mRNA levels for c-GPx4 remain largely constant throughout embryo development, expression profiles of the m-GPx4 and n-GPx4 isoforms appear to be under stage-dependent control and both enzymes obey to similar expression kinetics (Borchert et al., 2006)

Therefore, the development of novel, safer, and more effective therapies for the clinical management of women with PCOS and their metabolic complications remains an unmet medical need

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