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High concentrations of fumarate bind to glutathione, augmenting ROS signaling and accumulation, as observed in not only in vitro models but also in vivo models 136,137
EX-4 treatment reduces tau hyperphosphorylation levels in the hippocampus, a key area for memory and AD development [65]
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10.1073/pnas.0507498102 64 NakanoY.AsadaK
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