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Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice

Biomech Model Mechanobiol 11 , 439447, (2012)

In addition, the clearance of apoptotic trophoblasts causes the IL-10 production, and suppression of inflammatory cytokines by macrophages, suggesting that efferocytosis plays an important role in maternal-tolerance [23], while in the post-lactation apoptotic cell clearance at the mammary gland drives tissue remodeling [24]

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Signs and symptoms Although the genetic mutation is present at birth, it may take many years for copper to build up to levels where symptoms develop