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95% CI: 0.090.98

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At the receptor level, IGF-1 LR3 binds the IGF-1 receptor (IGF1R) and activates its intrinsic tyrosine kinase domain, which initiates downstream signaling through the PI3K/AKT and MAPK/ERK cascades

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Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway

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