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Ex-4 modulates apoptotic pathways in the hippocampus through the regulation of the expression levels of Bcl2, Bax, and caspase-3 [71], and it improves mitochondrial function and integrity in AD mice through the PI3K/Akt signaling pathway [72]

As for alcohol drinking, the role of ghrelin itself for alcohol responses is further unclear as general knockout of ghrelin and neutralization of circulating ghrelin results in different alcohol outcomes

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Yet in most patients this GI distress is not severe enough to stop treatment, though it is reported in approximately 40% of patients (compared to 20% on placebo)

PubMed: 16099219