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Kidney outcomes with glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, and sulfonylureas in type 2 diabetes and moderate cardiovascular risk

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Medicinal chemistry efforts have generated analogs and functional derivatives to address Erastins poor solubility, metabolic instability, and limited usability in vivo (75)

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WS-917 binds ABCB1, stimulates its ATPase activity, and reverses resistance by increasing intracellular paclitaxel by 730-fold, with low toxicity and synergy with CD8 + T-cell responses