Notably, SURMOUNT-2 specifically evaluated tirzepatide in individuals with type 2 diabetes, demonstrating superiority over both GLP-1 monotherapy and insulin-based regimens
At 32 weeks, 48.0% of participants on mazdutide 6 mg achieved both HbA1c below 7% and at least 10% body weight reduction, compared to just 21.0% on semaglutide 1 mg
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The co-primary endpoints were the percentage change of weight reduction in the Tirzepatide 10mg and 15mg dose groups at week 72 and the percentage of participants achieving 5% body weight reduction at 72 weeks compared to placebo
Guidance for industry: pharmacokinetics in patients with impaired renal function: study design, data analysis, and impact on dosing and labeling
S., Tan, B