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First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Gu et al., 2025)
Additionally, protein-rich foods tend to be more satiating, helping to curb cravings and reduce overall calorie intake
In clinical trials, many people found that starting with a lower dose and gradually increasing it helped reduce these effects
J.1991 58
Supporting natural metabolic function This is where microdosing creates an opportunity
6 HolmanRRPaulSKBethelMAMatthewsDRNeilHAW
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