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Activation of the Nrf2/HO-1 pathway restores N-acetylcysteine-induced impairment of the hypothalamus-pituitary-adrenal axis negative feedback by up-regulating GR expression and down-regulating GR expression into pituitary glands

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PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and 3 and enzymes involved in hepatic carnitine synthesis