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Ethics declarations Conflicts of interest The authors have no relevant financial or non-financial interests to disclose

This may contribute to the sustained suppression of lipogenic genes (e.g

Here, we fill this knowledge gap by identifying TBC1D9B, a poorly characterized endo-lysosomal member of the Tre-2/Bub2/Cdc16 (TBC) domain protein family 28 , as a negative regulator of ARL8B function and an interaction partner of the multispanning lysosomal membrane protein TMEM55B 29,30,31

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