pfizer oral glp 1 Pfizer's Appetite for More Obesity Meds Leads to $150M Deal for GLP-1 Drug From China Pfizer Nixes Twice-Daily Oral GLP-1

It is considered a compound of nutritional interest because of its role in the energy metabolism , as it facilitates the transport of long-chain fatty acids into the mitochondria, where they can be used to produce energy

Additionally, the medication's effects on gut motility and the gastrointestinal microenvironment have not been extensively studied in the context of active intestinal inflammation

Rather than conducting a new meta-analysis, the authors synthesize findings from major randomized clinical trials, highlighting outcomes related to glycated hemoglobin (HbA1c), body weight reduction, major adverse cardiovascular events (MACE), and kidney function decline as reported in large cardiovascular outcomes trials (CVOTs), obesity randomized controlled trials, and early-phase clinical development studies

PMID: 33524359

A 2020 meta-analysis in Clinical Nutrition ESPEN (Asbaghi et al.) pooled 12 randomized controlled trials and found that oral berberine reduced body weight by 2.07 kg and BMI by 0.47 kg/m2 versus control

Implications for anti-oxidation, anti-inflammation, anti-aging, cellular detox, brain health, and more