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Prog Neuropsychopharmacol Biol Psychiatry 31(7):14931499

FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms

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Mitophagys dual role depends on stress severity: pathological mitophagy (e.g., via PINK1/Parkin) releases iron and promotes ferroptosis, whereas basal mitophagy maintains mitochondrial quality to suppress ROS (Chang et al., 2024)

Below, we discuss some of the potential effects