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In studies using dehydroepiandrosterone (DHEA), an inhibitor of G6PD (that is also an adrenal steroid), loss of G6PD function has been suggested to prevent cancer progression 20,21

Samples for measurements with GSH were also supplemented with 1 U GR and 100 M NADPH to remove traces of GSSG and to maintain a highly reducing redox state

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Kariya expects to begin a Phase I trial in September

Key causes include dehydration, nutrient-poor heme-rich diets, and substances like alcohol, tobacco, and certain medications that impair blood flow and accelerate cellular aging