Most people dont see weight loss at the initial dose (0.25 mg once a week) of semaglutide (the generic form of Ozempic, which is used to treat diabetes, and its sister drug Wegovy which is approved for weight loss)
But clinically, that doesnt necessarily mean the medication has stopped working
[35] 1298AA is the "normal" homozygous, 1298AC the heterozygous, and 1298CC the homozygous for the "variant"
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Effects on quality of life, major adverse CV events & mortality are likely limited or uncertain. November 2025 Pdf of factsheet : Semaglutide binds to, and activates, the GLP-1 (glucagon-like peptide-1) receptor to increase insulin secretion, suppress glucagon secretion, and slow gastric emptying