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Unlike traditional sexual-enhancement drugs, PT-141 works directly at the level of the brain, eliciting a natural sexual response by interacting with the hypothalamus

Keywords: polycystic ovary syndrome, semaglutide, oxidative stress, autophagy Introduction Polycystic ovary syndrome (PCOS), a typical reproductive endocrine system disease with high incidence rate among childbearing age women, has developed into one of the important pathological factors leading to female infertility

N Engl J Med 375(19):18341844 Zinman B, Bhosekar V, Busch R, Holst I, Ludvik B, Thielke D et al (2019) Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial

- Upregulates tight junction proteins (e.g., Claudin), reducing transepidermal water loss (TEWL)

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The high followed the ADA retatrutide readout