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The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1
Not sure if this was due to uncertainty around work, dislike of my work location (we moved co-working spaces into a larger shared space), low-grade stress about paper edits, lack of protein, or some third thing
Zhou JY, et al
The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough
Others find that the acid stimulation worsens GERD-related burping
The goal is to reduce avoidable muscle loss and support body composition
