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In SURMOUNT-1, tirzepatide showed mean losses that reached about 20.9% at 72 weeks at the highest dose studied
Trompier D, Chang XB, Barattin R, du Moulinet DHardemare A, Di Pietro A, Baubichon-Cortay H
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The team emphasizes that despite these differences, both medications require gradual dose escalation, consistent adherence, and lifestyle changes for best results
If you notice these changes, skip that site for two weeks and switch to a different abdominal location
What happens to our muscles when we discontinue GLP-1s after weight loss
![Tirzepatide vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data]](https://www.clinicalnutritioncenter.com/wp-content/uploads/2026/04/research-image-2026-04-10.jpg)
