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DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
Patients were randomized in a 5:1:1 ratio to either WEGOVY 7.2 mg, WEGOVY 2.4 mg or placebo once weekly
IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 [PMID: 33573338] Laboratory literature summary: IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 Expression
Organ Growth Concerns at High Doses Because IGF-1 acts on all tissue not just muscle megadosing for extended periods may promote organ tissue hypertrophy, including intestinal walls and heart tissue
When including all treated participantsthose who completed the trial and those who discontinuedweight loss averaged 23.7%: still substantial, but meaningfully lower than the 28.7% efficacy headline
