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A Caco-2 bidirectional transport assay showed an apparent permeability (P app ) of 34.2 10 6 cm/s from apical to basolateral and 45.2 10 6 cm/s from basolateral to apical, with an efflux ratio of 1.33, indicating high permeability and no significant efflux

The NAD connection: sustained NAD availability from NNMT inhibition has downstream effects that are not fully mapped across cell types

AOD 9604 was engineered to bypass these pathways

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PubMed Ng, F.M., Sun, J., Sharma, L., Libinaki, R., Jiang, W.J., & Gianello, R

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