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Combined, they could form a next-gen weight loss injections stack, targeting appetite, metabolism, and energy expenditure
The medication works by mimicking the naturally occurring GLP-1 hormone, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite
GLP-1R can also couple with adenyl cyclase using other G s subtypes such as G i and G q [44, 45]
Unlike single-pathway weight loss medications, tirzepatide stimulates both GLP-1 and GIP receptors, making it more effective in controlling hunger, prolonging the feeling of fullness, and improving insulin sensitivity
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For more on the early phase of taking GLP-1s, read this article regarding what to expect in your first month on a GLP-1 medication
